Description
Patients with symptoms of depression often exhibit low levels of folate and vitamin B12. The human body needs sufficient folate intake to produce the essential neurotransmitters serotonin, dopamine and norepinephrine. These neurotransmitters alleviate feelings of sadness, anxiety and gloom.
Uses: DENOVO® PLUS B12 is a dietary supplement used for the metabolic management of low folate & B12 levels associated with symptoms of depression.
Directions:
Take one capsule daily, in the morning, or as recommended by your healthcare professional.
Active Ingredients: 25,000 mcg DFE of Folate (as 15 mg calcium L-5-methyltetrahydrofolate) & 2,000 mcg vitamin B12 (as 2 mg methylcobalamin)
Inactive Ingredients: microcrystalline cellulose, capsule (gelatin, titanium dioxide), vegetable magnesium stearate, & silica.
Warnings: Protect from heat, light, & moisture. Keep out of reach of children. Do not purchase if seal is broken. Folic acid, when administered in daily doses above 0.1 mg, may obscure the detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations). 5-MTHF may be less likely than folic acid to mask vitamin B12 deficiency. Folate therapy alone is inadequate for the treatment of a B12 deficiency. Methylcobalamin is counteracted with the consumption of alcohol. Serum B12 levels may be artificially elevated in patients with alcoholism, liver disease, or cancer. A major depressive episode may be the initial presentation of bipolar disorder. It is generally believed, although not established in controlled trials, that treating such an episode with an antidepressant alone may increase the likelihood of a precipitation of a mixed/manic episode in patients at risk for bipolar disorder. Denovo® plus B12 is not an antidepressant. However, 5-MTHF has been shown to enhance antidepressant effects of known antidepressants. Caution is recommended in patients with a history of bipolar illness. Patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder since mood elevation in this population is possible. DENOVO® PLUS B12 should always be used under medical supervision.
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